Correlation of Hypoxic Ischemic Encephalopathy Stages with Clinical Variables
Stages of Hypoxic Ischemic Encephalopathy
Background: Injury to the CNS related with perinatal asphyxia is referred to as Hypoxic-Ischemic Encephalopathy which is the utmost severe neurological condition that arises in perinatal periods. The aim is to assess clinical variables with hypoxic-ischemic encephalopathy stages. Subjects and Methods: A clinical study of 42 new borns asphyxiated were assessed clinically of these asphyxiated neonates was carried out using Sarnath and Sarnath Staging of HIE. The association between asphyxia at birth and HIE has been examined. Results: In the present study, maternal history, gestational age, and mode of delivery were found to be not significant and do not correlate with the severity of HIE. Sarnath and Sarnath clinical scoring for neurobehavioral signs and symptoms 13 (31%) had reveal of HIE stage -1, 14 (33%) are of stage -2 and severe HIE (HIE-III) common, seen in 15cases (36%). The correlation of non-stress test (NST), Meconium staining was more in stage-3 in HIE stages and statistically significant. Conclusion: During the diagnosis and treatment of HIE patients, analysis of clinical variables will improve the objectivity of newborn assessment and evaluation and early start of care.
Morales P, Bustamante D, Espina-Marchant P, Neira-Peña T, Gutiérrez-Hernández MA, Allende-Castro C. Pathophysiology of perinatal asphyxia: can we predict and improve individual outcomes? EPMA J . 2011;2(2):211–230. Available from: https://dx.doi.org/10.1007/s13167-011-0100-3.
Padayachee N, Ballot DE. Outcomes of neonates with perinatal asphyxia at a tertiary academic hospital in Johannesburg, South Africa. S Afr J Child Health. 2013;7(3):89–89. Available from: https://dx.doi.org/10.7196/sajch.574.
Angiti RR, Kumar P. Follow up of Neonates with Perinatal asphyxia. J Neonatol. 2004;18(2):22–27. Available from: https://dx.doi.org/10.1177/0973217920040205.
Committee on Foetus and Newborn, American College of Obstetricians and Gynecologists and Committee on Obstetric Practice Pediatrics. Pediatrics. 1996;98(1):141–2.
Robertson CM, Perlman M. Follow-up of the term infant after hypoxic-ischemic encephalopathy. Paediatr Child Health. 2006;11(5):278–282.
Sarnat HB, Sarnat M. Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study. Arch Neurol. 1976;33(10):696–705. Available from: https://doi.org/10.1001/archneur.1976.00500100030012.
Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling with mild sys- temic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005;365(9460):663–670. Available from: https://dx.doi.org/10.1016/s0140-6736(05)70932-6.
Lohan R, Chauhan G, Dalal A, Gupta SP, Bhardwaj AK, Ahlawat M. A Study on Incidence of Clinical Hypoxic Ischemic Encephalopathy Injury in Newborns with Perinatal Asphyxia. J Paediatr Child Health. 2016;1(1):1–4. Available from: https://dx.doi.org/10.15226/2576-4802/1/1/00104.
Dalal EA, Bodar NL. A study on birth asphyxia at the tertiary health center. Natl J Med Res. 2013;3(4):374–376.
Akka P, Pallavi. Correlation of clinical variables with hypoxic- ischemic encephalopathy stages. MIJOMED. 2018;8(2):41–43. Available from: https://doi.org/10.26611/1014821.
Milsom I, Ladfors L, Thiringer K, Niklasson A, Odeback A, Thornberg E. Influence of maternal, obstetric and fetal risk factors on the prevalence of birth asphyxia at term in a Swedish urban population. Acta Obstet Gynecol Scand. 2002;81(10):909–917. Available from: https://doi.org/10.1034/j.1600-0412.2002.811003.x.
Ziadeh SM, Sunna E. Obstetric and perinatal outcome of pregnancies with term labour and meconium-stained amniotic fluid. Archiv für Gynaekologie. 2000;264(2):84–87. Available from: https://dx.doi.org/10.1007/s004040000088.
Ash AK. Managing patients with meconium-stained amniotic fluid. Hosp Med. 2000;61(12):844–848. Available from: https://dx.doi.org/10.12968/hosp.2000.61.12.1482.
Portman RJ, Carter BS, Gaylord MS, Murphy MG, Thieme RE, Merenstein GB. Predicting neonatal Morbidity after perinatal asphyxia: a scoring system. Am J Obstet Gynecol. 1990;192(1):174–81. Available from: https://doi.org/10.1016/0002-9378(90)90844-w.
Sykes GS, Molloy PM, Johnson P, Gu W, Ashworth F, Stirrat GM, et al. Do Apgar score indicate Asphyxia? Lancet. 1983;1(8270):494–500. Available from: https://doi.org/10.1016/s0140-6736(82)91462-3.
Finer NN. Factors Affecting Outcome in Hypoxic-Ischemic Encephalopathy in Term Infants. Am J Dis Child . 1983;137(1):21–21. Available from: https://dx.doi.org/10.1001/archpedi.1983.02140270017006.
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