Magnitude of Bacteriological Etiology in Acute Encephalitis Syndrome: A Cross-Sectional Study
Magnitude of Bacteriological Etiology in Acute Encephalitis Syndrome
Background: Meningoencephalitis is an acute purulent infection within the subarachnoid space, it is associated with a CNS inflammatory reaction i.e. inflammation of brain and parenchyma both that may result in decreased consciousness, seizures, raised intracranial pressure and stroke. The present study was aimed to know the magnitude of bacteria that making picture of meningoencephalitis in AES among the children.Subjects and Methods: Present cross-sectional study was conducted in Children aged 1-15 yrs of age suffering from AES admitted in B.R.D Medical College, Gorakhpur. The study subject (children aged 1-15yrs suffering from AES) have been investigated for AES and bacterial etiology and subsequent comparison is made on the basic of clinical features, CSF findings and other lab findings. We divided our study in two parts, in first on the basic of our inclusion criteria we enrolled the patient and on a preplanned clinical proforma we did detailed clinical examination and investigate them accordingly. Cases with suspected AES were studied for their clinical features, recovery patterns and other biochemical and microbiological parameters. After the patient was admitted in the hospital, CSF, serum and stool samples were collected and stored at appropriate temperature. The samples were collected by resident doctor. Results: Out of 160 cases 16 case show culture positive result and among them Gm +vecocci was found in only 2 cases (2.5%). Gram negative cocci in 10(6.25%) cases and gram negative bacilli in 4 (2.5%) cases. The most common presenting symptoms were fever in 16 (100) cases followed by vomiting in 12 (75.00), headache in 10 (62.55) a seizure was in 10 (62.5) cases that was generalized tonic type. The CSF examination was suggestive that the majority of cases of AES were due to viral encephalitis. And 10% culture show positivity of bacteria in CSF . Meningeal sign like neck rigidity and kernign have significant association with bacterial culture positive result.Conclusion: The most common illness among AES patients observed in our study is Non-Bacterial but Japanese Encephalitis is still a problem in this region and it must not be neglected. Better diagnostic tests and standards to link an agent to encephalitis are needed in this field.