Analysis of Lipid Proﬁle in Subclinical Hypothyroidism at Tertiary Care Hospital-An Observational Study
Lipid Profile in Subclinical Hypothyroidism
Background : Subclinical hypothyroidism could damage vascular function by suggesting enhance in SVR and arterial rigidity and by changing endothelial purpose and so increasing the danger of atherosclerosis and coronary artery disease. The objective of this study is to analyze the relation amid SCH and serum lipid parameters in this subgroup. Subjects and Methods: Current research was performed for the duration of one year at the Department of Medicine, tertiary care institute of India, in patients diagnosed with Sub Clinical Hypothyroidism. Eighty patients were incorporated in the present study and 80 age- and sex-matched and regularly menstruating healthy controls, which were evaluated for the Thyroid Function test, were randomly recruited from staff and volunteers. T3, T4, and TSH were anticipated by utilizing quantitative hard stage ELISA, whereas TC was estimated with photometric determination according to the CHOD PAP method; TG and HDL were estimated by using the enzymatic colorimetric method. Results: There is a momentous augment in the serum TC stage in group II individuals 161.14 48.23 mg/dl when compared to group I 124.35 9.57 mg/dl, it is also a significant amplify in serum LDL-Cholesterol in group II individuals 97.99 32.42 mg/dl when compared to group I individuals 63.35 7.55. Conclusion: Subclinical hypothyroidism (SCH) is linked with increased serum TC and LDL-C levels. As a result, a prospective association amid subclinical hypothyroidism and atherosclerosis occurs. Larger studies are needed to prove this association in Indian patients.
Ayala AR, Danese MD, Ladenson PW. When to Treat Mild Hypothyroidism. Endocrinol Metab Clin North Am. 2000;29(2):399–415. Available from: https://dx.doi.org/10.1016/s0889-8529(05)70139-0.
Cooper DS. Subclinical hypothyroidism. JAMA. 1987;258(2):246–247. Available from: https://dx.doi.org/10.1001/jama.258.2.246.
Danese MD, Landenson PW, Meinert CL, Powe NR. Effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. J Clin Endocrinol Metab. 2000;85(9):2993–3001. Available from: https://doi.org/10.1210/jcem.85.9.6841.
Tunbridge WMG, Evered DC, Hall R, Appleton D, Brewis M, Clark F. The Spectrum of Thyroid Disease in a Community: The Whickham Survey. Clin Endocrinol. 1977;7(6):481–493. Available from: https://dx.doi.org/10.1111/j.1365-2265.1977.tb01340.x.
Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado Thyroid Disease Prevalence Study. Arch Intern Med. 2000;160(4):526–526. Available from: https://dx.doi.org/10.1001/archinte.160.4.526.
Pucci E, Chiovato L, Pinchera A. Thyroid and lipid metabolism. Int J Obes. 2000;24(S2):S109–S112. Available from: https://dx.doi.org/10.1038/sj.ijo.0801292.
Guntaka M, Hanmayyagari B, Rosaline M, Nagesh V. Lipid profile in subclinical hypothyroidism: A biochemical study from tertiary care hospital. CHRISMED J Health Res. 2014;1(4):266–266. Available from: https://dx.doi.org/10.4103/2348-3334.143014.
Biondi B, Cooper DS. The Clinical Significance of Subclinical Thyroid Dysfunction. Endocr Rev. 2008;29(1):76–131. Available from: https://dx.doi.org/10.1210/er.2006-0043.
Caraccio N, Ferrannini E, Monzani F. Lipoprotein Profile in Subclinical Hypothyroidism: Response to Levothyroxine Replacement, a Randomized Placebo-Controlled Study. J Clin Endocrinol Metab. 2002;87(4):1533–1538. Available from: https://dx.doi.org/10.1210/jcem.87.4.8378.
Ladenson PW, Wilson MC, Gardin J, Kronmal R, Kuller L, Tracy R. Relationship of subclinical hypothyroidism to cardiovascular risk factors and disease in an elderly population. Thyroid. 1994;4:18–18.
Klein I, Ojamaa K. Thyroid Hormone and the Cardiovascular System. N Engl J Med. 2001;344(7):501–509. Available from: https://dx.doi.org/10.1056/nejm200102153440707.
Rodondi N, Bauer DC, Cappola AR, Cornuz J, Robbins J, Fried LP, et al. Subclinical Thyroid Dysfunction, Cardiac Function, and the Risk of Heart Failure. J Am Coll. 2008;52(14):1152– 1159. Available from: https://dx.doi.org/10.1016/j.jacc.2008.07.009.
Vanderpump MPJ, Tunbrldge WMG, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol. 1995;43(1):55–68. Available from: https://dx.doi.org/10.1111/j.1365-2265.1995.tb01894.x.
Mansourian AR, Ghaemi E, Ahmadi AR, Marjani A, Saifi A, Bakhshandeh. Serum lipid level alterations in subclinical hypothyroid patients in Gorgan (Southeast of Caspian Sea). J Chinese Clin Med. 2008;31(4):206–216.
Paoli-Valeri M, Guzman M, Jimenez-Lopez V, Arias-Ferreira A, Briceno-Fernandez M, Arata-Bellabarba G. Perfil lipidico aterogenico enninos con hipotiroidismo subclinico. AP. 2005;62(2):128–162. Available from: https://doi.org/10.1157/13071309.
Duntas LH, Wartofsky L. Cardiovascular Risk and Subclinical Hypothyroidism: Focus on Lipids and New Emerging Risk Factors. What Is the Evidence? Thyroid. 2007;17(11):1075– 1084. Available from: https://dx.doi.org/10.1089/thy.2007.0116.
Duntas LH. Thyroid Disease and Lipids. Thyroid. 2002;12(4):287–293. Available from: https://dx.doi.org/10.1089/10507250252949405.
Lindeman RD, Schade DS, LaRue A, Romero LJ, Liang HC, Baumgartner RN, et al. Subclinical Hypothyroidism in a Biethnic, Urban Community. J Am Geriatr Soc. 1999;47(6):703–709. Available from: https://dx.doi.org/10.1111/j.1532-5415.1999.tb01593.x.
Bauer DC, Ettinger B, Browner WS. Thyroid Function and Serum Lipids in Older Women: A Population-based Study. Am J Med. 1998;104(6):546–551. Available from: https://dx.doi.org/10.1016/s0002-9343(98)00116-8.
Duntas LH, Mantzou E, Koutras DA. Circulating Levels of Oxidized Low-Density Lipoprotein in Overt and Mild Hypothyroidism. Thyroid. 2002;12(11):1003–1007. Available from: https://dx.doi.org/10.1089/105072502320908349.
Pirich C, Müllner M, Sinzinger H. Prevalence and relevance of thyroid dysfunction in 1922 cholesterol screening participants. J Clin Epidemiol. 2000;53(6):623–629. Available from: https://dx.doi.org/10.1016/s0895-4356(99)00187-0.
Miura S, Iitaka M, Yoshimura H, Kitahama S, Fukasawa N, Kawakami Y. Disturbed Lipid Metabolism in Patients with Subclinical Hypothyroidism: Effect of L-Thyroxine Therapy. Intern Med . 1994;33(7):413–417. Available from: https://dx.doi.org/10.2169/internalmedicine.33.413.
Hueston WJ. Subclinical Hypothyroidism and the Risk of Hypercholesterolemia. Ann Fam Med. 2004;2(4):351–355. Available from: https://dx.doi.org/10.1370/afm.79.
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