Estimation of Plasma BNP Levels in Rheumatic Heart Disease Patients at a Tertiary Care Teaching Hospital in Eastern India

Estimation of Plasma BNP Levels in Rheumatic Heart Disease Patients at a Tertiary Care Teaching Hospital in Eastern India

  • Deba Prasad Kar Department of Nephrology, IMS and SUM hospital, Siksha “O” Anusandhan University (Deemed to be), K8, Kalinga nagar, Bhubaneswar-751003, Odisha, India
  • Bandita Dash Department of health centre, National Institute of Science Education and Research, Bhubaneswar, Khurda 752050, Odisha, India
  • Anupam Agarwal Dept Nephrology VMMC and Safdarjang Hospital, New Delhi, 110029, India
  • Vijay Pratap Singh Consultant nephrologists Gorakhpur, Uttar Pradesh, India
  • Jatindra Nath Mohanty Medical Research Laboratory, IMS and SUM hospital, Siksha “O” Anusandhan University (Deemed to be), K8, Kalinga nagar,Bhubaneswar-751003, Odisha, India
Keywords: Rheumatic heart disease, Aortic stenosis, Systolic pulmonary artery, BNP

Abstract

Background: Brain natriuretic peptide (BNP) is a cardiac hormone secreted from the ventricular myocardium as a response to ventricular volume expansion and pressure overload. Rheumatic heart disease is a major health problem, mostly in developing country like India and particularly in this part of the country. In young age group rheumatic heart disease is the most common cause of cardiac morbidity and mortality. In this study our aim is to measure BNP levels in patients with RHD and to find out whether BNP concentrations correlate with clinical and echocardiographic findings. A total of 88 patients with rheumatic valve disease having different type of single or multivalvular lesions were included in this study.         BNP was measured using the chemiluminescence methods (Bayer Centure, Germany) by BNP kit. 2D Echocardiography with colour Doppler  was performed in all patients to assess the severity of the valve disease and for the measurement of pulmonary artery pressure. The plasma concentrations of BNP were found significantly higher in patients with aortic stenosis than in control  (355.92±204.31pg/ml vs.183.39±93.51pg/ml, p < 0.001). The plasma BNP level was significantly higher in NYHA class  IV than in class I (921.50±301.93 in class I  and  125.85±52.88 pg/ml, p < 0.001 in class III).   The independent determinants of higher BNP levels were NYHA functional class and systolic pulmonary artery pressure in multivariate analysis. Along with these results we got all other relative output which suggested that  increased plasma BNP levels in patients with rheumatic heart disease compared with healthy subjects.

Published
2019-11-27