Comparison of Clonidine and Dexamedetomidinein Reduction of Pressor Response during Endotracheal Intubation- A Prospective Study
Reduction of Pressor Response during Endotracheal Intubation
Background: Clonidine and dexmedetomidine have been used for attenuating sympathetic response to laryngoscopy and endotracheal intubation. Both these drugs have α-1 and α-2 receptors agonist activity but dexmedetomidine has selective α-2 receptor agonist activity which helps to blunt sympathetic response to laryngoscopy and tracheal intubation. Present study was performed to compare the effect of single dose clonidine and dexmedetomidine in attenuating pressor response to laryngoscopy and intubation. Subjects and Methods: This was a prospective, randomized, controlled study on 68 adult patients aged between 18 and 65 years in American Society of Anesthesiologists (ASA) physical status I and II undergoing elective surgeries under general anesthesia. The patients were allocated randomly into two groups of 34 patients each group received as Group A [Clonidine group]:1μg/kg iv in 20 ml normal saline over 10mins. Group B [Dexmedetomidine group]: 1μg/kgivin 20 ml normal saline over 10mins. Systolic blood pressure (SBP), Diastolic blood pressure (DBP), Mean arterial pressure (MAP), heart rate and SpO2 was noted after 5mins of drug administration, and again at the completion of study drug infusion. Results: There was no difference in HR, SBP, DBP& MAP between the two groups during the infusion of study drug. After laryngoscopy and intubation, the mean HR, SBP, DBP & MAP at 1st and 3rd minute was increased in Group A than Group B and it was statistically significant. Also, there was no significant difference between the mean HR of the two groups at 7th and 10th minute after intubation but group D had lower mean SBP, DBP & MAP compared to group C which was significant. Conclusion: Preremedication with dexmedetomidine in dose has significantly attenuated the hemodynamic pressor responses to laryngoscopy and intubation when compared to clonidine.