A Study to Compare and Evaluate the Efficacy of Granisetron and Granisetron Dexamethasone Combination as Anti-Emetic

Abstract

Background: Dexamethasone,  a  glucocorticoid  is shown to produce stronger antiemetic effect, probable  mechanism is prostaglandin  antagonism, serotonin inhibition, releasing endorphins and  5HT3 antagonism  with biological  half life  36 to 72 hrs, confers  longer  duration  of  prophylaxis.Since etiology of PONV is multifactorial , combination of different classes of antiemetic can increases clinical efficacy compared to single drug alone. Subjects and Methods: A detail preoperative assessment was performed on preoperative visit on the day before surgery. Where detail history, thorough general examination, airway assessment and systemic examination was performed. All routine investigations were done like haemogram, routine urine examination, random blood sugar, blood urea, serum creatinine and serum liver function test.X-ray chest and ECG were done when indicated.  Results: In Group-GD, only 13.33% had PONV which was statistically significantly low as compared to Group-G which was 36.66% (P<0.05). Complete response in Group-GD was 86.67% which was statistically significantly high as compared to Group-G which was only 63.34% (P<0.05). Conclusion: Requirement of Rescue anti-emetic was less in Granisetron-Dexamethasone combination group than Granisetron group.