The Effect of Three Different Bolus Doses of Propofol Using Total Intravenous Anaesthesia (TIVA) in Patients Undergoing Transvaginal Oocyte Retrieval with Regard to Total Propofol Consumption

Three Different Bolus Doses of Propofol Using Total Intravenous Anaesthesia

Abstract

Background: Total intravenous anaesthesia (TIVA) using propofol is one of the commonest techniques used for TVOR as a day care procedure by virtue of its adequate sedation and speedy clear headed recovery. Monitors like BIS or entropy help us to effectively titrate the drug so as to maintain optimal depth of anaesthesia and minimise drug consumption. Subjects and Methods: After obtaining Institutional Review Board approval, this prospective randomised controlled study was conducted in the Department of Anaesthesiology and Intensive care, Medical College Hospital. All ASA Grade I and II female patients of reproductive age group coming for oocyte retrieval under general anaesthesia who can understand the informed consent form were included in the study. Results: There is a statistically significant difference observed between group P1 and P3 with regard to Proportion of patients not requiring rescue boluses. No significant difference was observed between P1 P2 and P2-P3 groups. There was a statistically significant difference observed between groups P1 and P3 in respect to total propofol consumption. No significant difference observed between P1-P2 and P2-P3.  Conclusion: Bolus dose of propofol can be an induction dose of choice in oocyte retrieval patients as it requires less rescue boluses compared to 1.0mg/kg and and overall propofol consumption was less than 2 mg/kg but more than1 mg/kg.