Gabapentin and Tramadol for Prevention of Post Spinal Shivering

Prevention of Post Spinal Shivering

Abstract

Background: The study aims to compare gabapentin and tramadol for prevention of post spinal shivering. Subjects and Methods: A total of seventy- eight adult patients aged 2060 years were randomly divided into three groups of 26 patients each. Group I was administered two capsules of tramadol 50 mg each, Group II was administered two capsules of gabapentin 300 mg each and Group III was administered two sugar filled capsules. Results: The mean age was 43.5 years in group I, 44.6 years in group II and 45.3 years in group III, weight was 75.1 Kgs, 75.6 Kgs and 76.2 Kgs, height was 1.25 m, 1.26 m and 1.32 meters, BMI was 26.2 Kg/m², 26.5 Kg/m² and 1.32 Kg/m², duration of surgery was 81.3 minutes, 83.6 minutes and 84.7 minutes, duration of spinal anaesthesia was 186.4 minutes, 190.2 minutes and 191.5 minutes and onset of shivering was 34.2 minutes, 38.5 minutes and 32.4 minutes in group I, II and III respectively. A non- significant difference was observed (P> 0.05). Grade 0 was seen in 83%, 80% and 56% in group I, II and III respectively. Grade 1 was seen in 3%, 3%, grade 2 in 2%, 5%, grade 3 in 12%, 8% and 32% and grade 4 in 0%, 4% and 12% in group I, II and III respectively. Common adverse events reported were dizziness in 5%, 24%, Nausea/vomiting in 6%, 0% and 3% and hypotension in 13%, 6% and 14% in group I, II and III respectively. A significant difference was observed (P< 0.05). Conclusion:  Oral gabapentin 600 mg and tramadol 100 mg were found to be equally effective for prevention of post spinal shivering.