Evaluation of Ketamine-midazolam as Procedural Sedative Agent for Ease of Induction of Spinal Anesthesia in Patients Undergoing Abdominal Surgeries

Ketamine-midazolam as a Sedative Agent

Abstract

Background: Most of the patients are anxious during induction of spinal anesthesia may lead to poor positioning, autonomic fluctuations. Pro- viding procedural sedation may alleviate those undesired difficulties. In this study, we evaluated intravenous ketamine-midazolam combination as procedural sedative agent for ease of induction of spinal anaesthesia. Subjects and Methods: This prospective study was conducted among 60 patients who were randomly divided into 2 groups. Group K received Inj Ketamine 0.5mg/kg with Inj Midazolam 0.02mg/kg as procedural sedative agent prior to spinal anaesthesia, Group C did not receive any procedural sedative drugs. Ease of identification of space, time to induce spinal anaesthesia, number of attempts, patient comfort score, patient satisfaction score was recorded and analyzed. Results: Demographic data were comparable between the groups, there was no statistically significant difference between the groups in terms of ease of identification of space, number of attempts, time to induce spinal anaesthesia. Patient comfort score was significantly higher in group K compared to group C (9.17 0.59 and 7.13 1.20 respectively). Patient satisfaction score was higher in group K than group C (95.33 7.30 and 71.67 12.27  respectively). Conclusion: Intravenous Ketamine-midazolam as procedural sedative agent may not significantly ease the induction of spinal anesthesia compared to patients without sedation. However, it resulted in better satisfaction and comfort to the patient than without sedation.