Clinical Comparative Study between Fentanyl and Dexmedetomidine with Bupivacaine for Lower Limb Surgery in Spinal Anaesthesia:

Tuhin Vashishth; Sangeeta Varun

doi:10.21276/aan.2020.5.1.25

Tuhin Vashishth Associate professor, Department of Anaesthesia, LLRM Medical College Meerut,U.P, India
Sangeeta Varun Assistant professor, Department of Anaesthesia, LLRM Medical College MeerutU.P, India

DOI: https://doi.org/10.21276/aan.2020.5.1.25

Keywords: Bupivacaine, Dexmedetomidine, Fentanyl, spinal anesthesia

Abstract

Background: Spinal anesthesia is a preferred technique of choice in infraumbilical surgeries. The spinal anesthesia effect can be improved by adding various adjuvant like Fentanyl, clonidine, dexmedetomidine. Dexmedetomidine is a highly selective alpha 2 adrenergic agonists. The aim of study to compare efficacy and safety between Dexmedetomidine and Fentanyl with Bupivacaine.Subjects and Methods:A prospective randomized, double-blind study was conducted on 100 patient by dividing them into two groups. Group D: 2.5ml (12.5mg) of 0.5% hyperbaric bupivacaine with 5mcg (0.5ml) dexmedetomidine and Group F : 2.5ml(12.5mg) of 0.5% hyperbaric bupivacaine with 2 5mcg(0.5ml) fentanyl. The total volume injected intrathecally was 3.0ml in ASA I and II grade patient undergoing lower limb surgery.Results:Patients in dexmedetomidine groupD had a significantly longer sensory and motor block time than patients in fentanyl group F.The mean time of sensory regression to level S1 was 306.00 13 .32 in group D and 206.14 16.69 in group F(P<0.001). The regression time of motor block to reach modified Bromage 0 was 257.7014.61 in group D and 178.5414.23 in group F(P<0.001).Conclusion:Intrathecal Dexmedetomidine is associated with prolonging motor and sensory block as compare to Fentanyl.

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