A Comparative Study of Isobaric Levobupivacaine 0.5% versus Isobaric Levobupivacaine 0.5% with 3µg Dexmeditomidine in Spinal Anaesthesia in Patients Undergoing Effective Lower Limb Surgeries
Dexmeditomidine in Spinal Anaesthesia
Background: Intrathecal apha-2 agonists prolong the duration of action of local anesthetics and reduce the required dose. Dexmedetomidine is a 2 receptor agonist and its 2/1selectivity is 8 times higher than that of clonidine. Aim: In this study, we aimed to investigate the effect of adding 3µg dexmedetomidine to Intrathecal Isobariclevobupivacaine0.5% on the onset time and duration of motor and Sensory blocks.Study design: Randomized controlled study.Subjects and Methods:Patients were randomly assigned into two groups. Group L (n=30) patients received 3 mL (15mg) of 0.5% levobupivacaine+0.3mL normal saline and Group LD(n=30) patients received 3mL(15mg)of0.5%levobupivacaine+0.3mL (3mcg dexmedetomidine). Sensory block onset time, block reaching time to T10dermatome, the most elevated dermatome level, two dermatome regression time, sensory block complete regression time as well as motor block on a set time, reaching Bromage3and regressing to Bromage 0 were recorded.Results:Sensory and motor block onset times were shorter in Group LD than in Group L (p<0.001).The regression of the sensory block to S1dermatome andBromage0 was Longer in Group LD than Group L (p<0.001).The two dermatome regression time was Longer in Group LD than Group L (p<0.001). There were no statistically significant Differences between groups in blood pressure and hear trate.There was no statistically Significant difference between groups when adverse effects were compared.Conclusion:We conclude that intrathecal dexmedetomidine addition to Isobaric levobupivacaine 0.5%for spinal anaesthesia shortens sensory and motor block onset time and prolongs Block duration without any significant adverse effects.