A Clinical Comparative Study of Inj.Ropivacaine 0.75% with Inj.Dexmedetomidine (1.5?g/Kg) and Inj.Ropivacaine 0.75% with Inj. Clonidine (2?g/Kg) by Epidural Route in Patients Undergoing Lower Abdominal Surgeries

Lower Abdominal Surgeries

Abstract

Background: Regional Anaesthesia is an excellent choice which provides effective intra & post-operative analgesia with a single technique which is being possible due to the availability of long acting amide local anaesthetics like Ropivacaine and by the addition of adjuvants like clonidine and Dexmedetomidine. Aims: Compared the effects of Clonidine (2 mcg/kg) with Dexmedetomidine (1.5 mcg/kg) as an adjunct to Epidural 0.75 % Ropivacaine in lower abdominal surgeries in adult patients.Subjects and Methods:This is a prospective study carried out in 50 patients undergoing elective lower abdominal surgeries, aged between 18-45 years of either gender, belonging to ASA grade I and II randomly divided into two groups by lottery method.Results: The mean time of onset of sensory blockade in Dexmedetomidine group is significantly less than Clonidine group. The 2-segment regression time in Dexmedetomidine group was significantly higher than Clonidine group. The mean duration of sensory blockade was significantly higher with Dexmedetomidine group than Clonidine group. The mean time of onset of motor blockade was significantly less in Dexmedetomidine group than Clonidine group. The mean duration of motor blockade was significantly higher with Dexmedetomidine group than Clonidine group. The duration of analgesia was significantly prolonged and highest in the Dexmedetomidine group compared to Clonidine group. Both groups were similar in haemodynamic stability and side effects (P>0.05, statistically not significant).Conclusion:Dexmedetomidine was a better adjuvant than clonidine in epidural anaesthesia due to better patient tolerance, stable cardio-respiratory parameters, and where intra-operative and post-operative analgesia were concerned.