@article{Raja_Kalaichelvi_2019, title={Outcome Analysis of Cisplatin-5 Flurouracil and Weekly 5-Flurouracil in Advanced Gastric Cancer.}, volume={8}, url={https://aijournals.com/index.php/ajmr/article/view/539}, DOI={10.21276/ajmr.2019.8.1.MC1}, abstractNote={<p><strong>Background: </strong>Advanced gastric cancer patients has poor survival rate of &lt; 20% at 5 years. We intended to evaluate the outcomes of Cisplatin and 5-Flurouracil combination chemotherapy or 5 FU alone in this setting. <strong>Objectives:</strong> In this study we analyzed the outcomes such as response rate, progression free survival (PFS) at 6 months, and toxicity profiles of 3 weekly Cisplatin and 5-Flurouracil (PF) regimen and Weekly 5-Flurouracil (5-FU) therapy in advanced gastric cancer. <strong>Subjects and Methods:</strong> The outcomes of the chemotherapeutic regimens such as intravenous infusion of Cisplatin 75mg/m2 in divided doses and 5-Flurouracil 750mg/m2 for consecutive 3 days every 21 days (Group A) and intravenous infusion of 5-Flurouracil 500mg flat dose every week for 16 weeks (Group B) in stage III/IV gastric cancer were analyzed. Baseline parameters were obtained. <strong>Results: </strong>Twenty patients for both PF and weekly 5-FU regimens were recruited. The Overall response rate of Group A and B regimen was 40% and 20% respectively.&nbsp; PFS at the end 6 months was 60% and 35% respectively. Median time to progression was 5 months in group A and 3.6 months in group B.&nbsp; Hematological toxicity and Non hematological toxicity rates were in the acceptable range in Group A. <strong>Conclusion: </strong>Three weekly Cisplatin and 5-Flurouracil could be a good regimen when the performance status of the patient is good. Weekly 5-Flurouracil gives good quality of life and this regimen can be considered when the patient is not eligible for Cisplatin and 5-Flurouracil regimen in advanced gastric cancers.</p&gt;}, number={1}, journal={Asian Journal of Medical Research}, author={Raja, G. and Kalaichelvi, K.}, year={2019}, month={Mar.}, pages={MC01-MC04} }