Comparison of Antibiotic Sensitivity of Fusidic Acid and Mupirocin in S. Aureus Isolates in a Series of Community Acquired Pyodermas

Antibiotic Sensitivity of Fusidic Acid and Mupirocin in S. Aureus Isolates

Abstract

Background: Aim: To determine the sensitivity of topical antibiotics like fusidic acid and mupirocin in a series of 200 S.aureus isolates from community acquired pyodermas. Subjects and Methods: Prospective study conducted at the outpatient department of Dermatology, Venereology and Leprosy at AJ institute of Medical Sciences, Mangaluru between July to October 2018. All patients presenting to the outpatient department with primary or secondary pyodermas were eligible for the study. Patients of all age and both sex attending the outpatient department (OPD) of Dermatology with pyoderma after obtaining informed consent to participate in the study. Antibiotic sensitivity for fusidic acid and mupirocin was done for 135 cases and 101 cases respectively. Excluded patients where those who have had a hospital stay in the past one year, those who have already received topical or systemic antibiotics and non- consenting patients.The study was approved by the Institutes Review Board and Ethics Committee. Results: Total no of cases of resistance to mupirocin-0, Total no of cases of resistance to fusidic acid- 14. Conclusion: Mupirocin showed no resistance in any of our cases whereas 14 cases where resistant to fusidic acid.