The Possibility of APE1/Ref-1 as a Biomarker in the Detection of Coronary Artery Disease
APE1/Ref-1 as a Biomarker in the Detection of Coronary Artery Disease
Background: Coronary Artery Disease, was the leading cause of mortality globally resulting in more than 7 million deaths annually. APE1/Ref-1 is a multifunctional protein that is found in the nucleus of eukaryotic cells. Objective: To investigate the possibility of APE1/Ref-1 as a biomarker in the detection of Coronary Artery Disease in Indian population. Subjects and Methods: 100 subjects were divided into two groups of cases and controls. The Case group had Fifty patients diagnosed of Coronary Artery Disease on the basis of Clinical findings with Electrocardiography, Biochemical Markers, Echocardiography and Angiogram(wherever possible) attending the OPD of Department of Internal Medicine of SGT Hospital. Fifty age and gender matched healthy individuals constituted the control group. The data was statistically analyzed by using Student’s t-test and P values < 0.05 were considered statistically significant. Results: The difference in the mean of case and control values of APE1/Ref-1 is statistically significant. Conclusion: Our findings suggest that APE1/Ref-1 has a positive shows positive correlation with in patients of CAD.