The Possibility of APE1/Ref-1 as a Biomarker in the Detection of Coronary Artery Disease:

Vipul Bhasin; Busi Karunanand; Sanjiv Kumar Bansal; Vishu Bhasin

doi:10.21276/ajmr.2019.8.1.BC1

Vipul Bhasin Resident doctor, Department of Biochemistry, SGT Medical college, Haryana, India.
Busi Karunanand Head of Department, Department of Biochemistry, SGT Medical college, Haryana, India.
Sanjiv Kumar Bansal Professor, Department of Biochemistry, SGT Medical college, Haryana, India.
Vishu Bhasin Consultant Pathologist, Dr P Bhasin Path Labs, New Delhi, India.

DOI: https://doi.org/10.21276/ajmr.2019.8.1.BC1

Keywords: Coronary Artery Disease, APE1/Ref-1, Atherosclerotic Heart Disease, Atherosclerotic Cardiovascular Disease, Coronary Heart Disease

Abstract

Background: Coronary Artery Disease, was the leading cause of mortality globally resulting in more than 7 million deaths annually. APE1/Ref-1 is a multifunctional protein that is found in the nucleus of eukaryotic cells. Objective: To investigate the possibility of APE1/Ref-1 as a biomarker in the detection of Coronary Artery Disease in Indian population. Subjects and Methods: 100 subjects were divided into two groups of cases and controls. The Case group had Fifty patients diagnosed of Coronary Artery Disease on the basis of Clinical findings with Electrocardiography, Biochemical Markers, Echocardiography and Angiogram(wherever possible) attending the OPD of Department of Internal Medicine of SGT Hospital. Fifty age and gender matched healthy individuals constituted the control group. The data was statistically analyzed by using Students t-test and P values < 0.05 were considered statistically significant. Results: The difference in the mean of case and control values of APE1/Ref-1 is statistically significant. Conclusion: Our findings suggest that APE1/Ref-1 has a positive shows positive correlation with in patients of CAD.

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