Study on Single Dose Preoperative Antibiotic Prophylaxis versus Routine Long Term Postoperative Prophylaxis in Elective General Surgical Cases

Single Dose Preoperative Antibiotic Prophylaxis versus Routine Long Term Postoperative Prophylaxis

Abstract

Background: The preventive effect of the routine use of preoperative surgical antibiotic prophylaxis (SAP) on the occurrence of surgical site infections (SSI) prior to non-clean and implant surgery has long been recognized. Subjects and Methods: A total of 100 patients were included in the study and divided in to Group A and Group B. Group A contains patients with 1 g of cefotaxime sodium intravenously, that is, single dose was given 1 h before induction of anesthesia and Group B contains patients who were given first dose at 1 h before induction of anesthesia, and subsequent doses were given at an interval of 12 h after surgery for 5 days, that is, multiple dose. Results: This case comparative study were conducted in 100 cases, out of which 50 was included in Group A & 50 was included in Group B. In group A & B different surgical procedure have been done during the study period which is shown in table 1. In group A & B hernioplasty was done in 28% of total cases followed by other procedure. Conclusion: In can be concluded that single preoperative dose of cefotaxime sodium is cost-effective and is as effective as multiple-dose prophylaxis. In elective general surgical cases, it is a reliable method of prophylaxis.