Oxidative Stress and its Impact on Semen Quality

Abstract

Background: Male Infertility is on an inclining trend and there has been alarming rise of deteriorated semen quality in the past few decades. Recent evidences have suggested the role of elevated levels of oxidative stress and in impairing spermatogenesis. Therefore, in the present study effect of oxidative stress on semen quality has been explored. Objective: This study aimed to determine the relationship between oxidative stress (OS) and the results of semen analysis among men from infertile couples. Subjects and Methods: Hundred Semen samples from the males of infertile couple attending the infertility clinic JNMCH AMU were collected in the year 2016-2018 for detailed Semen analysis after proper consent.  Simultaneously Total Antioxidant Capacity and Oxidative stress status of semen samples was evaluated by colorimetric method. The effect of Oxidative stress on semen parameters was assessed using appropriate tests for both Quantitative and Qualitative variables. Results and Conclusion: There was significant reduction in Total sperm Concentration and sperm motility in semen samples with high Oxidative stress Index and low Total Antioxidant capacity, however semen volume and Morphology was unaltered. The result suggests that Oxidative stress has deleterious effect on semen parameters.