Association between High Density Lipoprotein (HDL) and Glycosylated Haemoglobin (HbA1c) in Type 2 Diabetes Mellitus Patients Undergoing Angiography for Acute Coronary Syndrome

High Density Lipoprotein and Glycosylated Haemoglobin in Diabetes Mellitus

Abstract

Background: To evaluate association between high density lipoprotein (HDL) and glycosylated hemoglobin (HbA1c) in type 2 diabetes mellitus patients undergoing angiography for Acute Coronary Syndrome (ACS). Subjects and Methods : Type 2 Diabetic patients who presented with Acute Coronary Syndrome were subjected to Angiography and Comparison of HDL & HbA1c level in view of single vessel or multi vessel Coronary Artery Disease was done to Evaluate association/correlation between HDL & HbA1c level with single/multi vessel Coronary Artery Disease. Result: In present study out of 90 subjects who have undergone C.A.G, 29 (32.22%) had S.V.D and 61 (67.78%) had M.V.D. In present study no. of male patients with S.V.D was 22 (75.86%) and females were 7 (24.14%). Whereas, no. of male patients with M.V.D were 45 (73.77%) and females were 16 (26.23%). Maximum no. of patients with S.V.D belong to age group <40 years (n=11, 37.93%). Maximum no. of patients with M.V.D belong to age group 51-60 years (n=26, 42.62%), Maximum patients had S.T.E.M.I i.e., n=73 (81.11%), whereas N.S.T.E.M.I was present in only 17 patients (18.89%). Among those with S.V.D, 72.41% (n=21) had HbA1c 6.5 to 8.4 and among 27.59% (n=8) had HbA1c >8.5. Among those with Multi vessel disease, 68.85% (n=42) had HbA1c >8.5 and 31.15% (n=19) had HbA1c of 6.5 to 8.4. There was significant inverse correlation present between level of H.D.L and number of vessel involved. Most of the patients with L.D.L 100 had Multi vessel disease (n=53, 86.99%). Conclusion: The severity of A.C.S, as measured by a single or multi-vessel disease on coronary angiography, is directly linked to poor glycemic management, as measured by a higher HbA1c. The severity of A.C.S is also linked to an abnormal lipid profile, such as elevated L.D.L and low-H.D.L.