To Compare Effectiveness and Safety of Teneligliptin vs Glimepiride in Patients with Type 2 Diabetes Mellitus

Effectiveness of Oral Hypoglycemic agents in Patients with Diabetes Mellitus

  • Arvind Sharma Postgraduate Student, Department of Medicine, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh, India. https://orcid.org/0000-0002-2596-1700
  • Alok Singhal Professor, Department of Medicine, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh, India
  • Vinod Kumar Singh Professor & Head, Department of Medicine, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh, India
  • Anmol Gera Postgraduate Student, Department of Medicine, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh, India
  • Singam Sumeeth Kumar Postgraduate Student, Department of Medicine, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh, India.
  • Sushrut Gupta Postgraduate Student, Department of Medicine, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh, India.
Keywords: Teneligliptin, Glimepiride, Type 2 Diabetes Mellitus

Abstract

Background:   To determine the efficacy of Teneligliptin [DPP-4 inhibitor] vs Glimepiride [sulfonylurea] in patients with type 2 diabetes mellitus. Materials and Methods: Patients with inadequate glycemic control with maximum tolerable dose of metformin were randomly divided into 2 groups (Group A & Group B). Group A was started on Teneligliptin and Group B on Glimepiride. The patients were assessed for weight, fasting plasma glucose (FPG), post parandial glucose (PPG), HbA1c and Lipid Profile. The patients were followed up in OPD for 3 months. The difference in all the mentioned parameters were used to determine the efficacy of Teneligliptin V/S Glimepiride. Result: There were more males as compared to females. Most of the subjects in both the groups were having age >50 years. Mean age in group A and B was 58.72±12.78 and 59.31±13.06 years individually. Family history of diabetes was discovered in 38.69% and 45.61% of the subjects in group A and B individually. The duration of diabetes was 42.11% and 47.37% of the subjects in group A and B since 5-10 years. Hypertension and cardiovascular disease were found in 14.04%, 5.26% and 19.30%, 3.51% of the subjects in group A and B. Lipid profile viz. Cholesterol, HDL, LDL and VLDL was similar among both the groups as p>0.05. Conclusion: In the current research, Glimepiride as well as Teneligliptin were very much endured when added to Metformin. Patients on Metformin+Teneligliptin displayed better command in control of glycemic profile as well as lipid profile. Thus, Teneligliptin is the better choice as an add-on medication to Metformin in type 2 diabetes patients.

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Published
2021-11-30
How to Cite
Sharma, A., Singhal , A., Singh , V. K., Gera , A., Kumar , S. S., & Gupta , S. (2021). To Compare Effectiveness and Safety of Teneligliptin vs Glimepiride in Patients with Type 2 Diabetes Mellitus. Academia Journal of Medicine, 4(2), 39-43. Retrieved from https://aijournals.com/index.php/ajm/article/view/2271