Causative Agents in Patients Presenting with Acute Viral Hepatitis along with their Clinical Profile at a Tertiary Care Hospital, Western U.P.

Acute viral Hepatitis clinical and etiological profile

  • Amit Mishra Assistant Professor, Department of Medicine, TMMC & RC, Moradabad, Uttar Pradesh, India
  • Shweta R Sharma Associate Professor, Department of Microbiology, TMMC & RC, Moradabad, Uttar Pradesh, India
Keywords: Acute viral hepatitis, acute liver failure, Anti -HEV

Abstract

Acute viral hepatitis (AVH) is a common health-related problem throughout the world, but morbidity and mortality are prevalently seen in developing countries like India. In India, AVH is most commonly caused by HAV (hepatitis A virus) and HEV (hepatitis E virus) and in few cases, HBV (Hepatitis B virus) is the etiological agent. HEV mainly affects the middle-aged population, is mild in symptoms however it is lethal with 30% mortality in pregnant females compared to the mortality of 1% in the general population. This study was focussed to identify the etiological agents, various clinical - laboratory factors, disease severity and associated complications in patients presenting with AVH. In our study, HEV was the most common etiological agent accounting for 43.6% of cases followed by HAV (29.1%), HBV (26.1%) and HCV (1.2%). The most common age group involved with AVH was the adult group i.e. from 21-30 yrs (35.1%) followed by 11-20 yrs (27.9%), below 10 yrs (15.1%) and 31-40 yrs (14.5%). The commonest symptom was yellow-colored urine (86.1%) followed by yellow discolouration of sclera and loss of appetite. Bleeding derangement was observed in all patients with acute liver failure (ALF) while Hepatic encephalopathy was observed in 3 patients with ALF. To conclude, integration of diagnostic measures, early diagnosis, treatment protocols, prevention and mass vaccination will help in the overall reduction of AVH cases and related complications.

Downloads

Download data is not yet available.

References

1. Rawat S, Gill PS, Gupta T, Malhotra P, Parmar A. Prevalence of hepatitis A virus and hepatitis E virus in the patients presenting with acute viral hepatitis in Rohtak. Haryana;.
2. Thiruvasagam P, George KJ, Arumugam S, Prasad AR, , , et al. IPSec: Performance Analysis in IPv4 and IPv6. J ICT Standardization. 2019;7(1):61–80. Available from: https://dx. doi.org/10.13052/jicts2245-800x.714.
3. Murhekar MV, Ashok M, Kanagasabai K, Ravi JV, Subari- nathan M, R. Epidemiology of hepatitis A and hepatitis E based on laboratory surveillance Data-India. Am J Trop Med Hyg. 2014;99:1058–61. Available from: https://dx.doi.org/10.4269/ ajtmh.18-0232.
4. Satsangi S, Chawla YK. Viral hepatitis: Indian scenario. Med J Armed Forces India. 2016;72(3):204–210. Available from: https://dx.doi.org/10.1016/j.mjafi.2016.06.011.
5. Hossain MS, Alam MR, Hasan MI, Sharif JU, Kabir MA, Islam MA. Prevalence of serological markers of viruses in patients of acute hepatitis. Mymensingh Med J. 2019;25:278–285.
6. Ringehan M, McKeating JA, Protzer U. Viral hepatitis and liver cancer. Philos Trans R Soc Lond B Biol Sci. 2017;372(1732):20160274. Available from: https://dx.doi.org/ 10.1098/rstb.2016.0274.
7. ; 2012. Available from: http://www.cdc.gov/nndss/document/ 2012_Case%20Definitions.pdf.
8. Desai H, Ansari AZ, Makwana D, Jadeja D, Gusani J. Clinical- biochemical profile and etiology of acute viral hepatitis in hospitalized young adults at tertiary care center. J Family Med Prim Care. 2020;9(1):247. Available from: https://dx.doi.org/ 10.4103/jfmpc.jfmpc_727_19.
9. Dabadghao V, Barure R, Sharma S, Mangudkar S. A study of the clinical and biochemical profile of acute viral hepatitis. Int J Biomed Adv Res. 2015;6:68993.
10. Shah NA, Kadla SA, Shafi PM, Dar IH. Clinico-serological profile of acute sporadic viral hepatitis in Kashimiri adults: Hospital based prospective study. JMSCR. 2014;2:3119–3145.
11. Acharya SK, Madan K, Dattagupta S, Panda SK. Viral hepatitis in India. Natl Med J India. 2006;19:203–220.
12. Nayak S, Panda M. VLSI Cell Partitioning Using Data Mining Approaches. International J Comput Sci Eng. 2018;6:1019– 1027. Available from: https://dx.doi.org/10.26438/ijcse/v6i8. 10191027.
13. Birajdar SV, Chavan SS, Mundhe SA, Bhosale MG. Clinical and biochemical profile of patients with viral hepatitis at tertiary care centre. Int J Adv Med. 2017;4(2):412. Available from: https://dx.doi.org/10.18203/2349-3933.ijam20171002.
14. Agrawal M, Ruchi K, Ashish B, Pallab S. A Study of Seroprevalence and Co-infection of Hepatitis A and Hepatitis E Viruses in Sporadic Cases in an Endemic Area. Int J Med Sci Public Health. 2016;02(03):1–5. Available from: https:
//dx.doi.org/10.46347/jmsh.2016.v02i03.001.
15. Handa S, Wasim S, Kalra BP, Rawat A, Chandar V, Gupta
A. Clinico-epidemiological profile of hepatitis A virus and hepatitis E virus co-infection in pediatric age group: a hospital based retrospective study. Int J Contemp Pediatr. 2019;6(2):588. Available from: https://dx.doi.org/10.18203/2349-3291.ijcp20190692.
16. Zhang S, Wang J, Yuan Q, Ge S, Zhang J, Xia N. Clinical characteristics and risk factors of sporadic hepatitis E in Central China. Virol J. 2011;8:1–5. Available from: https://dx.doi.org/ 10.1186/1743-422X-8-152.
Published
2021-06-02
How to Cite
Mishra, A., & Shweta R Sharma. (2021). Causative Agents in Patients Presenting with Acute Viral Hepatitis along with their Clinical Profile at a Tertiary Care Hospital, Western U.P. Academia Journal of Medicine, 4(1), 32-36. Retrieved from https://aijournals.com/index.php/ajm/article/view/1944