Alteration in Preoperative and Post-Operative Liver Functional Test in Gall Stone Patients- A Clinical Study

Abstract

Background: Alterations in serum lipid profile are known to occur in patients undergoing laparoscopic cholecystectomy. The present study was conducted to detect the alteration in preoperative and post-operative liver functional test in gall stone patients.Subjects and Methods:The present study was conducted on 126 patients of gall bladder stones of both genders. In all the patients, pre-operative assessment of liver function test such as SGOT (aspartate aminotransferase), SGPT (alanine aminotransferase), total bilirubin (TB), direct bilirubin (DB) and alkaline phosphatase (ALP) was performed. Patients underwent laproscopic cholecystectomy.Results:Out of 126 patients, males were 44 and females were 82. Preoperatively SGOT level was 22.08 U/L which increased to 80.4 U/L post operatively. SGPT level increased from 25.16 U/L to 82.8 U/L post operatively, total Bilirubin level increased from 0.92 to 1.64 U/L post operatively. DB increased from 0.38 to 0.56 U/L post operatively. Alkaline phosphatase level decreased from 65.42 to 64.26 U/L post operatively. The difference was significant (P< 0.05).Conclusion: There was alteration in aspartate aminotransferase, alanine aminotransferase, total bilirubin, direct bilirubin and alkaline phosphatase level in patients undergoing laproscopic cholecystectomy.