Assessment of Effect of Lump Size and Nodal Status on Prognosis of Invasive Breast Carcinoma

Invasive Breast Carcinoma

  • C. Asha Associate Professor, Department of General Surgery, Subbaiah Institute of Medical Sciences, Shivamogga, Karnataka, India
  • S. Vijay Kumar Professor, Department of General Surgery, Surabhi institute of Medical Sciences, Siddipet, Telangana, India
Keywords: Breast tumor, Lymph nodes, lump size

Abstract

Background: Latest report on national cancer registry website in India suggest breast cancer to be leading cancer in females in a population based survey, surpassing cervical cancer, at both urban and rural locations across India. The present study was conducted to assess effect of lump size and nodal status on prognosis of invasive breast carcinoma. Subjects & Methods: The study was done in Department of General Surgery for a period of six months from September 2019 to February 2020 in a tertiary care hospital among 45 women with invasive breast carcinoma was recorded. In all patients, side and location of tumour and histological types, tumour size, histological grade, skin, nipple and areola invasion was recorded. Results: Group I had 6, II had 8, III had 4, IV had 5, V had 2, VI had 6, VII had 7, VIII had 3 and IX had 4 patients. Location was upper outer quadrant (22), upper inner quadrant (5), lower outer quadrant (4), lower inner quadrant (3), center quadrant (9) and multifocal tumour (2). The difference was significant (P< 0.05). Conclusion: The size of the primary tumour and the number of positive lymph nodes has an inverse linear relationship with prognosis.

Downloads

Download data is not yet available.

References

Narod SA. Tumour size predicts long-term survival among women with lymph node-positive breast cancer. Curr Oncol. 2012;19:249–253. Available from: https://doi.org/10.3747/co.19.1043.

Pal SK, Mittal B. Improving cancer care in India: Prospects and challenges. Asian Pac J Cancer Prev. 2004;5(2):226–228.

Dass TA, Rakesh S, Prakash KP, Singh C. Correlation of Various Biomarkers with Axillary Nodal Metastases: Can a Panel of Such Biomarkers Guide Selective Use of Axillary Surgery in T1 Breast Cancer? Indian J Surg Oncol. 2015;6(4):346–351. Available from: https://dx.doi.org/10.1007/s13193-015-0424-x.

Cianfrocca M, Goldstein LJ. Prognostic and Predictive Factors in Early-Stage Breast Cancer. Oncologist. 2004;9(6):606–616. Available from: https://dx.doi.org/10.1634/theoncologist.9-6-606.

Sanderson RJ, Ironside JAD. Squamous cell carcinomas of the head and neck. BMJ. 2002;325(7368):822–827. Available from: https://dx.doi.org/10.1136/bmj.325.7368.822.

Singh S, Kwatra A, Aggarwal D, Gupta R, Chaturvedi AK, Kudesia M. Correlation of various histopathologic prognostic factors with Nottingham prognostic index and microvessel density in invasive breast carcinoma: A study of 100 cases. Indian J Cancer. 2015;52(1):110. Available from: https://dx.doi.org/10.4103/0019-509x.175594.

Shen SD, Zhong SZ, Wang CZ, Huang WH. Correlation of lymphovascular invasion with clinicopathological factors in invasive breast cancer: a metaanalysis. Int J Clin Exp Med. 2015;8(10):17789–17795.

Hernandez-Aya LF, Chavez-MacGregor M, Lei X, Meric- Bernstam F, Buchholz TA, Hsu L, et al. Nodal Status and Clinical Outcomes in a Large Cohort of Patients With Triple- Negative Breast Cancer. J Clin Oncol. 2011;29(19):2628– 2634. Available from: https://dx.doi.org/10.1200/jco.2010.32.1877.

Carter CL, Allen C, Henson DE. Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases. Cancer. 1989;63(1):181–187. Avail- able from: https://dx.doi.org/10.1002/10970142(19890101)63:1<181::aid-cncr2820630129>3.0.co;2-h.

Michaelson JS, Silverstein M, Sgroi D, Cheongsiatmoy JA, Taghian A, Powell S, et al. The effect of tumor size and lymph node status on breast carcinoma lethality. Cancer. 2003;98(10):2133–2143. Available from: https://dx.doi.org/10.1002/cncr.11765.

Garg M, Nagpal N, Sidhu DS, Singh A. Effect of lump size and nodal status on prognosis in invasive breast cancer: Experience from Rural India. J Clin Diagn Res. 2016;10(6):8–11. Available from: https://doi.org/10.7860/jcdr/2016/20470.8039.

Waks AG, Winer EP. Breast Cancer Treatment. JAMA. 2019;321(3):288. Available from: https://dx.doi.org/10.1001/jama.2018.19323.

Published
2020-12-31