A Study to Evaluate the Efficacy of Single Dose versus Multiple Dose of Pre Operative Antibiotic

Efficacy of Single Dose versus Multiple Dose of Pre Operative Antibiotic

  • Santosh Kumar Assistant Professor, Department of Surgery,Anugrah Narayan Magadh Medical College and Hospital, Gaya
  • Shri Krishna Ranjan Associate Professor, Department of Surgery, AnugrahNarayan Magadh Medical College and Hospital,Gaya
Keywords: Single dose vs. multiple dose, Antibiotic prophylaxis, cholecystectomy


Background: Our  study  is  aimed  to  compare  the  impact  of  single  vs. multiple  dose  of  antibiotic  in  cholecystectomy in terms of post-operative infection related complications.Subjects and Methods:The present studywas prospective and longitudinal.  Total 180 patients who were admitted for elective cholecystectomywere included in our study. The patientswere randomly divided in two equal groups:  single dose (SD) group and multiple dose (MD) group, comprising of 90 patients in each group. SD group was given ceftriaxone  (2 gm)  intravenously at  the  time of  induction of anaesthesia. Whereas, MD group was given  ceftriaxone  (2  gm)  intravenously  at  the  time  of  induction  of  anaesthesia  followed  by  ceftriaxone  (1  gm) intravenously twice a day for two days post-operatively.Results:In single dose antibiotic group, total post-operative infection rate was 4.4% and that in multiple dose groups was found to be 3.3%. Data was analyzed with Chi- square test and the difference in the rate of SSI in both the groups was found statistically insignificant.Conclusion: The rate of post-operative SSI after singledose antibiotic intravenously at inductionof anaesthesia is comparable with that of multiple dose antibiotics. So single dose antibiotic regimen can be safely practiced in elective cholecystectomy.