Evaluation of Gall Bladder Volume in Type 2 Diabetes Mellitus Patients Using Real Time Ultrasonography

Gall Bladder Volume in Type 2 Diabetes Mellitus

  • KS Jagadeesh Associate Professor, Department of Radiology, Akash Institute of Medical Sciences & Research Centre, Devanahalli, Bengaluru, Karnataka, India
  • Ashwini M. Patil Assistant Professor, Department of Radiology, Akash Institute of Medical Sciences & Research Centre, Devanahalli, Bengaluru, Karnataka, India


Background: Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Autonomic neuropathy manifests as esophageal dysfunction, nocturnal diarrhea, gall bladder dysfunction, sphincter disturbances, atonic bladder and orthostatic hypotension. The present study aimed to evaluate and compare the gall bladder volume  in fasting and post prandial state by real time ultrasound in Type 2 Diabetes Mellitus (T2DM) patients and healthy controls. Subjects and Methods: In this cross sectional study, 90 subjects were included. Among them, 45 were type 2 diabetes mellitus patients included as cases and 45 age and sex matched healthy controls, who attended the Department of Medicine and Radio-diagnosis, Akash Institute of Medical Sciences & Research Centre, Devanahalli, Bengaluru, Karnaaka. All the study subjects were underwent detailed general and systemic examinations. Under aseptic conditions, 3ml fasting blood samples were collected and used for the estimation of fasting blood sugar, post prandial blood sugar. Gall bladder volume evaluation in fasting and 45 minutes post prandial (standardized fatty meal) state were done in T2DM patients and controls using real time ultrasound (GE Voluson P8 Mechine). Results: In the present study, BMI (24.78 2.31 kg/m2), FBS (160.98 27.99 mg/dl), PPBS (244.31 38.91 mg/dl), Fasting gall bladder volume (33.33 6.42 cm3), post fatty meal gall bladder volume (15.21 6.39 cm3), ejection fraction (49.34 17.29 cm3) were significantly increased in type 2 diabetes mellitus patients compared with healthy controls. Conclusion: The study results conclude that, fasting and post-prandial gallbladder volumes are indicative of gallbladder function. Patients with type 2 diabetes mellitus showed statistically significant impairment of gallbladder function. Gallbladder function may be evaluated routinely in type 2 diabetes mellitus patients.


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Kharroubi AT. Diabetes mellitus: The epidemic of the century. World J Diabetes. 2015;6(6):850–854. Available from: https://dx.doi.org/10.4239/wjd.v6.i6.850.

Aynalem SB, Zeleke AJ. Prevalence of Diabetes Mellitus and Its Risk Factors among Individuals Aged 15 Years and Above in Mizan-Aman Town. Int J Endocrinol. 2018;2018:9317987. Available from: https://doi.org/10.1155/2018/9317987.

Omar SM, Musa IR, ElSouli A, Adam I. Prevalence, risk factors, and glycaemic control of type 2 diabetes mellitus in eastern Sudan: a community-based study. Ther Adv Endocrinol. 2019;10:1–8. Available from: https://dx.doi.org/10.1177/2042018819860071.

Wang S, Ma W, Yuan Z, Wang SM, Yi X, Jia H. Asso- ciation between obesity indices and type 2 diabetes mellitus among middle-aged and elderly people in Jinan, China: a cross- sectional study. BMJ Open. 2016;6(11):12742–12746. Avail- able from: https://doi.org/10.1136/bmjopen-2016-012742.

Nayak SB, Rahming V, Raghunanan Y, Raghoonath C, Rahman D, Rajh. Prevalence of diabetes, obesity and dyslipidaemia in persons within high and low income groups living in North and South Trinidad. J Clin Diagn Res. 2016;10(5):8–13. Available from: https://dx.doi.org/10.7860/JCDR/2016/18154.7875.

Babu GR, Murthy GVS, Ana Y, Patel P, R D, Neelon SEB, et al. Association of obesity with hypertension and type 2 diabetes mellitus in India: A meta-analysis of observational studies. World J Diabetes. 2018;9(1):40–52. Available from: https://dx.doi.org/10.4239/wjd.v9.i1.40.

Gaur C, Mathur, Agarwal A, Verma K, Jain R, Swaroop A. Diabetic autonomic neuropathy causing gallbladder dysfunction. J Assoc Phys India. 2000;48:603–605.

Raman PG, Patel A, V M. Gall bladder disorder and Type 2 diabetes mellitus. A clinical based study. J Assoc Phys India. 2002;50:887–890.

Stone BG, Gavaler JS, Belle SH, Shreiner DP, Peleman RR, Sarva RP, et al. Impairment of gallbladder emptying in diabetes mellitus. Gastroenterol. 1988;95(1):170–176. Available from: https://dx.doi.org/10.1016/0016-5085(88)90307-1.

Fraquelli M, Pagliarulo M, Colucci A, Paggi S, Conte D. Gallbladder motility in obesity, diabetes mellitus and coeliac disease. Digest Liver Dis. 2003;35:12–16. Available from: https://dx.doi.org/10.1016/s1590-8658(03)00087-2.

Steven M, Haffner, Andrew K. Clinical gallbladder disease in NIDDM subjects. Diabetes care. 1993;16(9):1276–1282. Available from: https://doi.org/10.2337/diacare.16.9.1276.

Chapman TMBA, Chapman CM, Frampton RJ, Chisholm RB, Allan IR, Wilson. Gallbladder volume comparison of diabetics and controls. Digestive Dis Sci. 1998;43(2):344–348. Available from: https://doi.org/10.1023/a:1018810523399.

Agarwal AK, Miglani S, Singla S, Garg U, Dudeja RK, Goel A. Ultrasonographic evaluation of gallbladder volume in diabetics. J Assoc Physicians India. 2004;52:962–967.

Ugbaja CA, Ayoola RTOO, Ikem BM, Idowu. Gall bladder volume and contractility in type 2 diabetes mellitus. Afr J Diabetes Med. 2015;23(2):9–12.

Rai G, Baghel V, Rai T, Vyas M. Gall bladder dysfunction in chronic diabetics (type 2): an ultrasonography based prospective study. Int J Res Med Sci. 2016;4(2):390–

Available from: https://dx.doi.org/10.18203/2320-6012.ijrms20160084.

How to Cite
KS Jagadeesh, & Patil, A. M. (2020). Evaluation of Gall Bladder Volume in Type 2 Diabetes Mellitus Patients Using Real Time Ultrasonography. Asian Journal of Medical Radiological Research, 8(1), 83-88. https://doi.org/10.47009/ajmrr.2020.8.1.15