Morphometric Analysis of Corpus Callosum in Patients with Hypoxic Ischemic Encephalopathy (HIE)

Morphometric Analysis of Corpus Callosum in Patients with Hypoxic Ischemic Encephalopathy (HIE)

  • Jain Avi Vinod P.G. Junior Resident, JJM Medical College, Davanagere, Karnataka
  • Jeevika M.V HOD, Department of Radiodiagnosis, JJM Medical College
  • Meghana S P.G. Junior Resident, JJM Medical College, Davanagere, Karnataka
  • Moinuddin Adil Mulla P.G. Junior Resident, JJM Medical College, Davanagere, Karnataka
  • Hita Shivayogi P.G. Junior Resident, JJM Medical College, Davanagere, Karnataka
  • Anusha BK P.G. Junior Resident, JJM Medical College, Davanagere, Karnataka

Abstract

Background: Corpus callosum (CC)- largest white matter structure in brain and has an important role in communicating both cerebral hemispheres. Damage to CC during development has been associated with poor neurological outcome, poor neuropsychological performance, cognitive and communication developmental delays.Aim and Objectives: Morphometric analysis of Corpus Callosum (CC) in HIE patients in comparison with CC of normal subjects by using MRI.Subjects and Methods: Retrospective comparative study of 40 patients-Ages < 2 year. Cases(20patients)-diagnosed cases of  HIE on MRI. Controls (20patients)-proven to be normal on MRI. Two groups- ≤1 year and 1- 2 year age-group. Study was done on T1-mid-sagittal sections of brain obtained on PHILIPS-Achieva 1.5-Tesla-MRI.Statistical Data analysis of different measurements was done using‘t’ test and ‘p’ values.  Results&Conclusion: Variables were affected in order of Splenium>Body>Genu >Isthmus in ≤1year age-group and Genu>Splenium>Body>Isthmus in >1year age-group when mean value of different variables were compared between cases and controls. In HIE cases, thickest part was Genu and thinnest part was Isthmus.No statistically significant difference was found between males and females. This is one of the few studies providing biometric comparison between the CC of HIE patients and their controls. Damage to the CC during development is associated with poor neurological and neuropsychological performance, cognitive and communication developmental delays. This study analyzes the pattern of involvement of different variables of CC in HIE patients and helps in predicting the poor neurological outcome and developmental delays.

Published
2020-01-11
How to Cite
Jain Avi Vinod, Jeevika M.V, Meghana S, Moinuddin Adil Mulla, Hita Shivayogi, & Anusha BK. (2020). Morphometric Analysis of Corpus Callosum in Patients with Hypoxic Ischemic Encephalopathy (HIE). Asian Journal of Medical Radiological Research, 7(2), 178-183. Retrieved from http://aijournals.com/index.php/ajmrr/article/view/1284
Section
Articles