Transrectal Ultrasound Prostate Volume Correlation with Serum Prostate Specific Antigen Level in Patients with Prostatic Enlargement in Portharcourt

Transrectal Ultrasound Prostate Volume Correlation with Serum Prostate Specific Antigen Level

Abstract

Background: Prostatic enlargement is common among aging men which is associated elevation of serum prostate specific antigen (PSA) level. Prostatic enlargement could be due to benign prostatic hypertrophy, prostatitis, or prostatic neoplasms.Aim: The aim of this study is to determine transrectal ultrasound prostate volume (TPV) correlation with serum prostate specific antigen level in patients with prostatic enlargement. Subjects and Methods: One hundred and forty-three (143) males referred for ultrasound prostate evaluation with clinical diagnosis of prostatic enlargement that fulfill the study criteria were studied, using LOGIQ P6 PRO GE Healthcare machine fitted with 10MHz transrectal probe while the PSA level was estimated by Enzyme Immunoassay using DIAGNOSTIC INC PSA KIT.  The blood samples were collected before the ultrasonic evaluation. The anterio-posterior, transverse and cranio-caudal diameters of the prostate gland were obtained and the prostate volume generated by the ultrasound machine.  The data collected was analyzed using SPSS windows version 21.0 statistical software. Correlation between variables was determined using Pearson correlation coefficient and linear regression analysis.Results:The mean (Mean+SD) transrectalProstate Volume (TPV) and serum PSA levels were 66.13+30.43cm³ and 8.50+3.95ng/ml respectively. Pearsons Correlation between TPV and Serum PSA level gave a correlation coefficient (r) of 0.809 (pvalue of 0.01). TPV and Serum PSA concentrations did not show correlation with Body Mass Index.Conclusion: This study showed a significant correlation between transrectal prostate volume and serum PSA concentration in patients with prostate enlargement.  Therefore, TPV can be used as alternative method of estimating serum PSA concentration where direct measurement is absent.