Eﬀects of intravenous Dexmedetomidine on Intraoperative Hemodynamic Parameters in the Patients Undergoing Laparoscopic Cholecystectomy
Effects of intravenous Dexmedetomidine
Background: Dexmedetomidine, in addition to sympatholytic effect, diminishes intraoperative requirement of anesthetics including propofol. The present study was conducted to evaluate the effects of intravenous dexmedetomidine on intraoperative hemodynamics in laparoscopic cholecystectomy. Subjects and Methods: Five patients undergoing laparoscopic cholecystectomy received dexmedetomidine. Dexmedeto- midine was loaded (1 µg/kg) before anesthesia induction and infused (0.6 µg/kg/h) during surgery. Anesthesia was induced with propofol. Mean arterial pressure (MAP) and heart rate (HR) were recorded at baseline and at various time points from the loading of drugs to just after tracheal extubation. Results: Both HR and MAPdecreased till insufflation and then increased at extubation. Conclusion: During propofol-based anesthesia for laparoscopic cholecystectomy, dexmedetomidine provides stable intraoperative hemodynamics.
Khare A, Sharma SP, Deganwa M, Sharma M, Gill N. Effects of dexmedetomidine on intraoperative hemodynamics and propofol requirement in patients undergoing laparoscopic cholecystectomy. Anesth Essays Res. 2017;11(4):1040–1045. Available from: https://dx.doi.org/10.4103/aer.aer_107_17.
Yazbek-Karam VG, Aouad MM. Perioperative uses of dexmedetomidine. Middle East J Anesth. 2006;18:1043–58.
Slogoff S, Keats AS. Does Perioperative Myocardial Ischemia Lead to Postoperative Myocardial Infarction? Anesthesiology. 1985;62(2):107–114. Available from: https://dx.doi.org/10.1097/00000542-198502000-00002.
Ohtani N, Kida K, Shoji K, Yasui Y, Masaki E. Recovery Profiles from Dexmedetomidine as a General Anesthetic Adju- vant in Patients Undergoing Lower Abdominal Surgery. Anesth Analg. 2008;107(6):1871–1874. Available from: https://dx.doi.org/10.1213/ane.0b013e3181887fcc.
Copyright (c) 2020 Author
This work is licensed under a Creative Commons Attribution 4.0 International License.