Estimation of Adenosine Deaminase Levels in CSF in Different Etiology of Meningitis
Estimation of Adenosine Deaminase Levels in CSF in Different Etiology of Meningitis
Abstract
Background: Meningitis is the most common sequelae to microbial invasion of the CNS and is more common in the developing countries than developed countries. Its Neurological sequalae are serious and rather common among survivors. Aim: To assess the difference in ADA activity in CSF in different types of meningitis and to differentiate between various etiologies of meningitis including pyogenic, tuberculous and viral meningitis using ADA levels in CSF. Subjects and Methods: The study included fifty patients (n=50) of meningitis, admitted in emergency, indoor medical wards and ICU of Guru Nanak Dev Hospital, Amritsar. The CSF specimens were obtained by lumbar puncture using all the aseptic precautions. CSF ADA was recorded by Giusti and Galantimethod. Results: Mean ADA levels in TBM was 19.098.16 IU/l, In pyogenic meningitis was3.9- 6.391.26 IU/l while in viral meningitis was 6.571.30 IU/l. On comparison, CSF ADA was found to be markedly raised in TB meningitis, while lower ADA values are seen in PM and VM. Conclusion: It can be concluded that ADA estimation in CSF is inexpensive and rapid anda reliable method for diagnosis of tuberculousetiology in TBM as CSF ADA levels are is markedly raised in tubercular meningitis, while lower ADA values are seen in pyogenic meningitis and viral meningitis.