Assessment of Correlation of Vitamin D Level with Coronary Artery Disease

Correlation of Vitamin D Level with Coronary Artery Disease

Keywords: Coronary Artery Disease, Dyslipidemia, Vitamin D

Abstract

Background: Cardiovascular disease (CVD) is the leading cause of death in the developed world. The present study was conducted to assess correlation of plasma 25-Hydroxy-Vitamin D level with angiographic severity in coronary artery disease. Subjects and Methods: The present study was conducted on 120 patients of CAD. Group I were cases and group II were control. Hypertension, type II diabetes mellitus status, smoking etc. was recorded. 2 ml of blood sample was taken from all patients and measurement of 25(OH) vit D levels was performed. Results: The mean BMI in group I was 24.6 kg/m2 and 24.8 kg/m2 in group II, smoking habit was seen in 78 in group I and 34 in group II, hypertension was seen in 65 in group I and 26 in group II, diabetes was seen in 52 in group I and 30 in group II, alcoholism in 36 in group I and 10 in group II, dyslipidemia was seen in 48 in group I and 15 in group II. The mean 25 (OH) vitamin D in group I was 15.1 ng/ml and 19.6 ng/ml in group. The difference was significant (P< 0.05). Maximum dyslipidemia (80.5%) patients had low vitamin D level followed by DM, smoking, BMI, alcoholism and alcoholism. There was no correlation between risk factors and vitamin D deficiency (P> 0.05). Conclusion: Authors found that in cases, vitamin D level was lowered as compared to control, however, there was no correlation between risk factors and CAD.

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References

Targher G, Bertolini L, Padovani R, Zenari L, Scala L, Cigolini M, et al. Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol. 2006;65(5):593–597. Available from: https://dx.doi.org/10.1111/j.1365-2265.2006.02633.x.

Sugden JA, Davies JI, Witham MD. Vitamin D improves endothelial function in patients with type 2 diabetes mellitus and low vitamin D levels. Diabet Med. 2008;25:320–325.

van Etten E, Mathieu C. Immunoregulation by 1,25- dihydroxyvitamin D3: Basic concepts. J Steroid Biochem Mol Biol. 2005;97(1-2):93–101. Available from: https://dx.doi.org/10.1016/j.jsbmb.2005.06.002.

Lai H, Fishman EK, Gerstenblith G, Brinker JA, Tong W, Bha- tia S, et al. Vitamin D deficiency is associated with significant coronary stenoses in asymptomatic African American chronic cocaine users. Int J Cardiol. 2012;158(2):211–216. Available from: https://dx.doi.org/10.1016/j.ijcard.2011.01.032.

Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M, et al. Effect of Vitamin D Deficiency and Replacement on Endothelial Function in Asymptomatic Subjects. J Clin Endocrinol Metab. 2009;94(10):4023–4030. Available from: https://dx.doi.org/10.1210/jc.2008-1212.

Pilz S, Dobnig H, Fischer JE, Wellnitz B, Seelhorst U, Boehm BO, et al. Low Vitamin D Levels Predict Stroke in Patients Referred to Coronary Angiography. Stroke. 2008;39(9):2611– 2613. Available from: https://dx.doi.org/10.1161/strokeaha.107.513655.

Reis JP, von Mühlen D, Michos ED, Miller ER, Appel LJ, Araneta MR, et al. Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis. Atherosclerosis. 2009;207(2):585–590. Available from: https://dx.doi.org/10.1016/j.atherosclerosis.2009.05.030.

Chitalia N, Recio-Mayoral A, Kaski JC, Banerjee D. Vita- min D deficiency and endothelial dysfunction in non- dialysis chronic kidney disease patients. Atherosclerosis. 2012;220(1):265–268. Available from: https://dx.doi.org/10.1016/j.atherosclerosis.2011.10.023.

Khazai N, Judd SE, Tangpricha V. Calcium and vitamin D: Skeletal and extraskeletal health. Curr Rheumatol Rep. 2008;10(2):110–117. Available from: https://dx.doi.org/10.1007/s11926-008-0020-y.

Tarçın O, Yavuz DG, Özben B, Telli A, Öğünç AV, Yüksel M. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab. 2009;94:4023–4053.

Akin F, Ayça B, Köse N, Duran M, Sarı M, Uysal OK, et al. Serum Vitamin D Levels Are Independently Associated With Severity of Coronary Artery Disease. J Invest Med. 2012;60(6):869–873. Available from: https://dx.doi.org/10.2310/jim.0b013e31825457cb.

Baktır AO, Dogan Y, Sarlı B, Sahin O, Demirci E, Akpek M, et al. Relationship between serum 25-hydroxyvitamin D levels and the SYNTAX score in patients with acute coronary syndrome. Anatolian J Cardiol. 2017;17(4):293–293.

Published
2020-06-25
How to Cite
Shaik, R. B. S., & Madhumitha, R. (2020). Assessment of Correlation of Vitamin D Level with Coronary Artery Disease. Academia Journal of Medicine, 3(1), 70-73. https://doi.org/10.47008/ajm.2020.3.1.14