Dengue Fever and its Dermatological Changes

Dengue Fever and its Dermatological Changes

  • Mohan Kumar R Associate Professor, Department of General Medicine, Oxford Medical College, Bangalore
  • Muddu Surendra Nehru Associate Professor, Department of General Medicine, Nimra Institute of Medical Sciences, Jupudi (V), Ibrahimpatnam (M), Krishna (Dist), Andhra Pradesh
Keywords: Dengue fever, dermatological rash

Abstract

Background: Around the world dengue incidence has dramatically grown with a large number of asymptomatic cases. Worldwide about 390 million dengue infections were occurring per year, among them 96 million people were developing clinical manifestations with varied severity. About 3.9 billion people residing in 128 countries, were at-risk of dengue virus infection. Dengue fever (DF) is one of the common causes of acute febrile illness. In half the patients with dengue fever skin involvement occurs. Aim & Objectives: To study the socio-demographic parameters, clinical features and laboratory parameters among the patients with and without skin rash in dengue infection. Also determine outcome among the patients with dengue fever and its association with skin rash. Subjects and Methods: A hospital-based, analytical prospective study was conducted in the Department of General Medicine, Sapthagiri Institute of Medical Sciences and Research Center, Bangalore. Patients older than 16 years of age with clinical features and laboratory reports suggestive of dengue infection were included. The study was conducted for a period of 12 months from 1st December 2014 to 30th November 2015. These patients were further divided based on the skin rash presence and absence. The data obtained was entered in Microsoft Excel and analyzed in SPSS version-22 trial. Analysis was done using unpaired students t-test, ANOVA. Results: In total 97 patients with dengue fever were enrolled into the study. About 14.4 p.c (14) patients were with skin rash. The patients with skin rash were found to have lower platelet levels during the disease course. Patients with skin rash had higher percentage of platelet transfusion which was statistically significant. Conclusion: A cutaneous involvement may facilitate clinical diagnosis but it may not be present among all the patients.

Downloads

Download data is not yet available.

References

Back AT, Lundkvist A. Dengue viruses – an overview. Infect Ecol Epidemiol. 2013;3:1–21. Available from: https://dx.doi.org/10.3402/iee.v3i0.19839.

Abhilash KPP, Mitra S, Gautam I, Jambugulam M, Jayaseeelan

V. Clinical score to differentiate scrub typhus and dengue: A tool to differentiate scrub typhus and dengue. J Global Inf Dis. 2017;9:12–17. Available from: https://dx.doi.org/10.4103/0974-777x.199996.

Koshy M, Mishra AK, Agrawal B, Kurup AR, Hansdak SG. Dengue fever complicated by hemophagocytosis. Oxford Medical Case Reports. 2016;2016:121–124. Available from: https://dx.doi.org/10.1093/omcr/omw043.

Gubler DJ. Epidemiology of arthropod-borne viral diseases. Monath TP, editor. Boca Raton, Fla: CRC Press, Inc; 1988.

Gubler DJ. Dengue and Dengue Hemorrhagic Fever. Clin Microbiol Rev. 1998;11(3):480–496.

Hayes EB, Gubler DJ. Dengue and dengue hemorrhagic fever. Pediatric Inf Dis J. 1992;11(4):311–317. Available from: https://dx.doi.org/10.1097/00006454-199204000-00010.

Cassetti MC, Thomas SJ. Dengue Human Infection Model: Introduction. J Infect Dis. 2014;209(Suppl 2):S37–S39. Available from: https://dx.doi.org/10.1093/infdis/jiu061.

Simmons CP, Farrar JJ, V NV, Wills B, Dengue. N Engl J Med. 2012;12(15):1423–1455.

Thomas EA, John M, Kanish B. Mucocutaneous manifestations of Dengue fever. Indian J Dermatol. 2010;55(1):79–85. Available from: https://dx.doi.org/10.4103/0019-5154.60359.

Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL. The global distribution and burden of dengue. Nature. 2013;496(7446):504–507. Available from: https://dx.doi.org/10.1038/nature12060.

Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG, et al. Refining the Global Spatial Limits of Dengue Virus Transmission by Evidence-Based Consensus. PLoS Neglected Trop Dis. 2012;6:e1760–e1760. Available from: https://dx.doi.org/10.1371/journal.pntd.0001760.

Waterman SH, Gubler DJ. Dengue fever. Clin Dermatol. 1989;7(1):117–122. Available from: https://dx.doi.org/10.1016/0738-081x(89)90034-5.

Thomas E, John M, Kanish B. Mucocutaneous manifestations of dengue fever. Indian J Dermatol. 2010;55:79–85. Available from: https://dx.doi.org/10.4103/0019-5154.60359.

Published
2020-05-18
How to Cite
Mohan Kumar R, & Muddu Surendra Nehru. (2020). Dengue Fever and its Dermatological Changes. Academia Journal of Medicine, 3(1), 11-14. https://doi.org/10.47008/ajm.2020.3.1.3