Association of Birth-Weight, Obesity and Family History in the Development of Latent Autoimmune Diabetes in Adults (LADA) and Type 2 Diabetes Mellitus

Association of Birth-Weight, Obesity and Family History in the Development of Latent Autoimmune Diabetes in Adults (LADA) and Type 2 Diabetes Mellitus

  • Shubhangi Verma MD (General Medicine), Professor, Department of General Medicine, Dr. PDMMC, Amravati, (Maharashtra)
  • Samarth Sharma MD (General Medicine), Assistant Professor,Department of General Medicine,Sri Shankaracharya Medical College, Bhilai, Durg (Chhattisgarh)
  • Priyadershini Rangari MDS (Oral Medicine and Radiology), Assistant Professor, Department of Dentistry, Sri Shankaracharya Medical College, Bhilai, Durg (Chhattisgarh)
Keywords: Birth weight, Diabetes, latent autoimmune diabetes in adults (LADA), Type 2 Diabetes Mellitus (T2DM)

Abstract

Background: A proportion of subjects with adult-onset autoimmune diabetes does not require insulin-therapy at the time of diagnosis and are clinically similar to patients with type 2 Diabetes Mellitus (T2DM). Objectives: The present study was undertaken association of birth-weight, obesity and family history in the development of latent autoimmune diabetes in adults (LADA) and type 2 Diabetes Mellitus. Subjects and Methods: A total of 50 healthy controls, 50 type 2 diabetic and 50 patients with LADA were enrolled. Complete demographic details of all the patients were obtained. Clinical examination of all the patients was carried out and medical history of all the patients was obtained. Detailed medical history and family history of all the patients was recorded separately. A Performa was made and complete anthropometric parameters were recorded. Body mass index (BMI) was calculated. All the results were recorded in Microsoft excel sheet and was analysed by SPSS software. Results: While assessing association of birth-weight in the development of latent autoimmune diabetes in adults (LADA) and type 2 Diabetes Mellitus; it was observed that significantly higher proportion of patients of the diabetic group and the LADA group had low birth-weight in comparison to the patients of the control group. While assessing association of family history of diabetes in the development of latent autoimmune diabetes in adults (LADA) and type 2 Diabetes Mellitus; it was observed that significantly higher proportion of patients of the diabetic group and the LADA group had positive family history of diabetes in comparison to the patients of the control group. While assessing association of obesity in the development of latent autoimmune diabetes in adults (LADA) and type 2 Diabetes Mellitus; it was observed that mean BMI of the patients of the diabetic group and the LADA group was significantly higher in comparison to the patients of the control group. Conclusion: Low birth weight, obesity and positive family history of diabetes are important risk factors in the development of latent autoimmune diabetes in adults (LADA) and type II diabetes.

Published
2020-01-03