Renal Biopsy Findings in Lupus Nephritis and Their Correlation with Clinico-Biochemical Parameters

Renal Biopsy Findings in Lupus Nephritis and Their Correlation with Clinico-Biochemical Parameters

  • Vivek C Ganiger Department of Nephrology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India
  • Deba Prasad Kar Department of Nephrology, IMS and SUM hospital, Siksha “O” Anusandhan University (Deemed to be), K8, Kalinga nagar, Bhubaneswar-751003, Odisha, India
  • Bandita Dash Department of health centre, National Institute of Science Education and Research, Bhubaneswar, Khurda 752050, Odisha, India
  • Anupam Agarwal Dept Nephrology VMMC and Safdarjang Hospital, New Delhi, 110029, India
  • Jatindra Nath Mohanty Medical Research Laboratory, IMS and SUM hospital, Siksha “O” Anusandhan University (Deemed to be), K8, Kalinga nagar,Bhubaneswar-751003, Odisha, India
Keywords: Renal biopsy, lupus nephritis, SLE, Clinical & biochemical parameters

Abstract

Background: This is an observational analysis wherein we contemplated renal biopsy discoveries of 50 patients of lupus nephritis (LN) and these biopsy discoveries were associated with clinical and biochemical parameters of the LN patients. The study included 50 patients of SLE diagnosed to have renal involvement. Renal biopsy was done in every one of the 50 patients and the outcomes were ordered by the ISN/RPS arrangement of LN. Clinical and biochemical parameters were examined in all patients and they were corresponded with renal biopsy discoveries. The different biochemical parameters in our investigation were-proteinuria (100%) , raised serum creatinine (56%). Mean 24 hour protein discharge was 2386+/ - 1810 mg/day at presentation.11(22%) patients had nephrotic range proteinuria and 8 (16%) patients had proteinuria <1gm/day. Nephrotic range proteinuria was seen in LN Class IV and Class V. Hematuria was available most ordinarily in LN Class IV (in 100%) while none of the Class II LN patients had hematuria. Hypertension was most ordinarily connected with Class III and Class IV LN. Mean serum creatinine was 2.53+/ - 1.92 mg/dl. Mean serum creatinine was relatively higher on Class IV LN than in different classes of LN. In our examination most regular kind of renal biopsy finding in lupus nephritis was LN Class IV. Most serious kind of LN is Class IV LN. LN patients may have mixed lesions of Class IV and Class V LN, which was found in 2 patients (4%) in our investigation. LN Class I and LN Class VI are exceptionally uncommon at introduction of LN which were not found in renal biopsy in our examination.

Published
2019-11-27