Comparison of e?cacy of Ondansetron and Metoclopramide in reducing Postoperative Nausea and Vomiting

Ondansetron Vs Metoclopramide

Abstract

Background: Post-operative vomiting and nausea are common conditions faced by cases undergoing surgery under general anesthesia. Ondansetron and metoclopramide are the widely used drug which was proved to reduce the post-operative vomiting and nausea but among metoclopramide and ondansetron, the one drug with better efficacy remains a question and hence this study was conducted to assess the same. Subjects and Methods : This randomized controlled trial was conducted in the department of anesthesiology among the patients who underwent surgery in Sri Muthukumaran Medical College Hospital and Research Institute, Chennai from August 2019 to March 2020. A total of eighty cases were included and the study participants were randomized and divided into two groups with forty cases in each group. Patients in group A received the drug Metoclopramide (10 mg) and group B received Ondansetron (4 mg). Outcome assessed were the incidence of nausea and vomiting and the number of doses of additional antiemetics needed. Data was analyzed using SPSS -17. Results: There was no statistically significant difference noted between the two groups for age, gender, weight and duration of surgery whereas vomiting and nausea were found to be significantly low in the ondansetron group compared to the metoclopramide group which in turn results in significantly more doses of antiemetics were needed in the metoclopramide group than the ondansetron group during the post-operative period. Conclusion: Single dose of preoperative ondansetron helps to significantly reduce postoperative nausea and vomiting compared to metoclopramide.