Clonidine as an Adjuvant to Intrathecal Bupivacaine for Infraumbilical Surgery

Clonidine as an Adjuvant to Intrathecal Bupivacaine for Infraumbilical Surgery

  • Deepa Allolli Associate Professor, Department of Anesthesia, Al-Ameen Medical College, Vijayapur, Karnataka
  • G S Mahishale Associate Professor, Department of Medicine, Al-Ameen Medical College, Vijayapur, Karnataka
  • Mrudula M Watwe Professor, Department of Anesthesia, Al-Ameen Medical College, Vijayapur, Karnataka
  • Rajendra Kumar B Professor, Department of Anesthesia, Al-Ameen Medical College, Vijayapur, Karnataka
  • Nazeer Ahmed K Professor, Department of Anesthesia, Al-Ameen Medical College, Vijayapur, Karnataka
  • Shilpa Deshpande Senior Resident, Department of Anesthesia, Al-Ameen Medical College, Vijayapur, Karnataka
Keywords: Alpha2 adrenoreceptor agonist, clonidine, intrathecal anesthesia, spinal anesthesia

Abstract

Background: Clonidine is a partial α2 adrenoreceptor agonist which has been shown to interact synergistically with local anesthetics. The present study was aimed to evaluate and compare the effect of 75 mcg of clonidine added to 3 ml of 0.5% bupivacaine, with respect to duration of sensory block and motor block, hemodynamic parameters, and associated side effects.Subjects and Methods: Patients scheduled to undergo infraumbilical surgery during the study period were randomly allocated to receive either 3 ml 0.5% bupivacaine and 0.5 ml 0.9% normal saline or 3 ml 0.5% bupivacaine and 0.5 ml 75 mcg injection clonidine. Various intraoperative parameters were noted and compared between the control and clonidine group.Results: Baseline characteristics of the patients were similar in both the study groups. Onset of motor block was significantly shorter in the clonidine group (378.55 ± 23.92 seconds vs 350.26 ± 21.22 seconds; p value < 0.001), duration of motor block and time for two segment regression was significantly higher in the clonidine group (158 ± 8.2 minutes vs 186.14 ± 9.15 minutes; p value < 0.001 and 78.97 ± 7.18 minutes vs 102.70 ± 5.61 minutes; p value <0.001 respectively). The hemodynamic parameters and side effect profile was found to be similar among patients in both the study groups.Conclusion: 75 mcg clonidine used as an adjunct with 3 ml of 0.5% bupivacaine for spinal anaesthesia in patients undergoing infraumbilical surgeries provides better sensory and motor blockade.

Published
2019-12-23
How to Cite
Deepa Allolli, G S Mahishale, Mrudula M Watwe, Rajendra Kumar B, Nazeer Ahmed K, & Shilpa Deshpande. (2019). Clonidine as an Adjuvant to Intrathecal Bupivacaine for Infraumbilical Surgery. Academia Anesthesiologica International, 4(2), 295-298. https://doi.org/10.21276/aan.2019.4.2.66