Effect of Preoperative Ketamine and Magnesium Sulfate on Intra & Postoperative Analgesia in Laparoscopic Cholecystectomy: A Comparative Randomized Controlled Study

Intra & Postoperative Analgesia in Laparoscopic Cholecystectomy

Abstract

Background: The pain management using N-methyl-D-aspartate antagonist drugs like ketamine and magnesium sulfate during intraoperative, and postoperative period plays a major role by reducing the opioid usage. A comparative randomized controlled study was assessed to identify the best analgesic drug among two different N-methyl-D-aspartate antagonists in laparoscopic cholecystectomy patients. Subjects and Methods: Enrolled patients were equally divided into three groups 20 for each group, First group were administered with normal saline bolus, group 2 with ketamine and group 3 with magnesium sulfate as preoperative analgesic. Results: The results showed that ketamine group consumed 53.66% less fentanyl over the controls and 14.64% in magnesium sulfate. Cumulative morphine consumption was 10.22 mg in controls, 7.22 mg in ketamine and 6.5 2 mg in magnesium groups were resulted a less consumption of postoperative morphine. There are no symptoms like nausea, vomiting, and pruritus was observed. Thus Ketamine and magnesium both were found to be effective in reducing introperative and post operative analgesic consumption. Conclusion: Therefore, it could be concluded that the preoperative usage of ketamine and magnesium sulfate was safe and reduces requirement of opioid for the major surgeries.